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The principle of requires that people not be coerced into participating in research.Events like these forced the reexamination of ethical standards and the gradual development of a consensus that potential human subjects needed to be protected from being used as 'guinea pigs' in scientific research.By the 1990s, the dynamics of the situation changed.From the time immediately after World War II until the early 1990s, there was a gradually developing consensus about the key ethical principles that should underlie the research endeavor.Two marker events stand out (among many others) as symbolic of this consensus.


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